Antibody response to a filarial antigen fraction in individuals exposed to Wuchereria bancrofti infection in India.
Identifieur interne : 00AA45 ( Main/Exploration ); précédent : 00AA44; suivant : 00AA46Antibody response to a filarial antigen fraction in individuals exposed to Wuchereria bancrofti infection in India.
Auteurs : M. Bal [Inde] ; M K DasSource :
- Acta tropica [ 0001-706X ] ; 1999.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (immunologie), Diéthylcarbamazine (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Filaricides (usage thérapeutique), Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Filarioses (immunologie), Humains, Immunité innée (immunologie), Immunoglobulines (sang), Inde (épidémiologie), Setaria (nématode) (immunologie), Sujet âgé, Test ELISA, Vieillissement (immunologie), Wuchereria bancrofti (immunologie).
- MESH :
- immunologie : Antigènes d'helminthe, Filariose lymphatique, Filarioses, Immunité innée, Setaria (nématode), Vieillissement, Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- sang : Anticorps antihelminthe, Immunoglobulines.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Filaricides.
- épidémiologie : Filariose lymphatique, Inde.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Humains, Sujet âgé, Test ELISA.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aging (immunology), Animals, Antibodies, Helminth (blood), Antigens, Helminth (immunology), Child, Child, Preschool, Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Enzyme-Linked Immunosorbent Assay, Filariasis (immunology), Filaricides (therapeutic use), Humans, Immunity, Innate (immunology), Immunoglobulins (blood), India (epidemiology), Middle Aged, Setaria Nematode (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , blood : Antibodies, Helminth, Immunoglobulins.
- geographic , epidemiology : India.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- immunology : Aging, Antigens, Helminth, Elephantiasis, Filarial, Filariasis, Immunity, Innate, Setaria Nematode, Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- chemical , therapeutic use : Diethylcarbamazine, Filaricides.
- Adolescent, Adult, Aged, Animals, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Humans, Middle Aged.
Abstract
An antigen fraction (DssdI) was isolated from the aqueous-insoluble components of adult Setaria digitata. Rabbit antiserum to DssdI labeled the sheaths of Wuchereria and Setaria microfilariae suggesting DssdI to be surface associated. Antibody responses to DssdI were determined in Wuchereria bancrofti exposed individuals. IgM titre was highest in endemic normals (EN; asymptomatic amicrofilaraemic) followed by chronic filarial patients (CP) and asymptomatic microfilaraemics (AS). IgG titer was high in both chronic filariasis and endemic normals. The microfilaraemic group had the lowest titer. The seropositivity rate in AS was 28% for IgG and 10% for IgM, in CP 100% for IgG and 33% for IgM, and in EN 86% for both antibodies. An age-dependency of IgM but not of IgG antibodies was observed in endemic normals, with IgM prevalence reaching a plateau by 12 years of age. The subclass composition of the antibody response to DssdI appeared to be primarily IgG3 in endemic normals, IgG1 in chronic filariasis and IgG4 in asymptomatic microfilaraemics. Diethylcarbamazine (DEC) treatment led to a significant increase in IgG and IgM levels in microfilaraemic individuals. Of interest, the expression of IgG subclasses altered. There was an increased IgG3 and IgG1 response associated with a reciprocal decrease in IgG4 following DEC therapy.
PubMed: 10232782
Affiliations:
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Le document en format XML
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Bal</name><affiliation wicri:level="1"><nlm:affiliation>Parasite Immunology Division, Regional Medical Research Centre (ICMR), Bhubaneswar, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Parasite Immunology Division, Regional Medical Research Centre (ICMR), Bhubaneswar</wicri:regionArea><wicri:noRegion>Bhubaneswar</wicri:noRegion></affiliation></author><author><name sortKey="Das, M K" sort="Das, M K" uniqKey="Das M" first="M K" last="Das">M K Das</name></author></analytic><series><title level="j">Acta tropica</title><idno type="ISSN">0001-706X</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aging (immunology)</term><term>Animals</term><term>Antibodies, Helminth (blood)</term><term>Antigens, Helminth (immunology)</term><term>Child</term><term>Child, 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xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Filariose lymphatique</term><term>Filarioses</term><term>Immunité innée</term><term>Setaria (nématode)</term><term>Vieillissement</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Aging</term><term>Antigens, Helminth</term><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Immunity, Innate</term><term>Setaria Nematode</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobulines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Inde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Sujet âgé</term><term>Test ELISA</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An antigen fraction (DssdI) was isolated from the aqueous-insoluble components of adult Setaria digitata. Rabbit antiserum to DssdI labeled the sheaths of Wuchereria and Setaria microfilariae suggesting DssdI to be surface associated. Antibody responses to DssdI were determined in Wuchereria bancrofti exposed individuals. IgM titre was highest in endemic normals (EN; asymptomatic amicrofilaraemic) followed by chronic filarial patients (CP) and asymptomatic microfilaraemics (AS). IgG titer was high in both chronic filariasis and endemic normals. The microfilaraemic group had the lowest titer. The seropositivity rate in AS was 28% for IgG and 10% for IgM, in CP 100% for IgG and 33% for IgM, and in EN 86% for both antibodies. An age-dependency of IgM but not of IgG antibodies was observed in endemic normals, with IgM prevalence reaching a plateau by 12 years of age. The subclass composition of the antibody response to DssdI appeared to be primarily IgG3 in endemic normals, IgG1 in chronic filariasis and IgG4 in asymptomatic microfilaraemics. Diethylcarbamazine (DEC) treatment led to a significant increase in IgG and IgM levels in microfilaraemic individuals. Of interest, the expression of IgG subclasses altered. There was an increased IgG3 and IgG1 response associated with a reciprocal decrease in IgG4 following DEC therapy.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Das, M K" sort="Das, M K" uniqKey="Das M" first="M K" last="Das">M K Das</name></noCountry><country name="Inde"><noRegion><name sortKey="Bal, M" sort="Bal, M" uniqKey="Bal M" first="M" last="Bal">M. Bal</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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